Hormones & TRT/HRT Adjuncts

Anastrozole

Also known as Arimidex

Clinically studiedOralFDA-approved for breast cancer in postmenopausal women; use in men is off-label; prescription only; aromatase inhibitors are banned in sport (WADA, category S4)

Anastrozole is a non-steroidal aromatase inhibitor, a small-molecule drug rather than a peptide. It blocks the aromatase enzyme that converts androgens (including testosterone) into estrogen, thereby lowering circulating estradiol. It is FDA-approved for hormone-receptor-positive breast cancer in postmenopausal women and is used off-label in men on testosterone therapy to manage estrogen-related effects.

Studied / used for

Used off-label to reduce estradiol in men on testosterone therapy who have elevated estrogen
FDA-approved and used for hormone-receptor-positive breast cancer in postmenopausal women
Studied for raising testosterone in some hypogonadal men by reducing estrogen feedback

Commonly reported side effects

Hot flashes
Joint pain and stiffness (arthralgia)
Reduced bone mineral density with long-term use
Fatigue
Nausea
Mood changes
Potential adverse effects on lipids/cardiovascular markers

Clinically studied. Supported by human clinical trials. This reflects the strength of the research base, not effectiveness or a recommendation.

Not medical advice.

This is an educational reference. Peptalk does not recommend, prescribe, endorse, or rate any compound, and provides no dosing information. Do not start, stop, or change any peptide, hormone, supplement, or therapy based on this page. All clinical decisions must be made with your licensed healthcare provider.

← Back to all compounds