Metabolic & Weight Management

AOD-9604

Also known as HGH fragment 176-191 · growth hormone fragment

PreliminarySubcutaneous injectionOralNot FDA-approved as a drug; development as an obesity medication was discontinued around 2007. Has been granted GRAS status as a food ingredient (distinct from drug approval); in the US, accessed via compounding pharmacies on prescription.

AOD-9604 is a synthetic peptide corresponding to a C-terminal fragment of human growth hormone (the segment that gives rise to its alternate name, HGH fragment 176-191). It was engineered to mimic the lipolytic (fat-mobilizing) actions of growth hormone without its effects on blood glucose or growth. Early-phase trials reported it was generally tolerated but did not show enough efficacy to advance as a commercial obesity drug.

Studied / used for

researched for fat metabolism and lipolysis
researched as an adjunct for body composition

Commonly reported side effects

injection-site reactions reported
headache reported
limited adverse effects reported in early trials

Preliminary. Mostly early or animal studies. This reflects the strength of the research base, not effectiveness or a recommendation.

Not medical advice.

This is an educational reference. Peptalk does not recommend, prescribe, endorse, or rate any compound, and provides no dosing information. Do not start, stop, or change any peptide, hormone, supplement, or therapy based on this page. All clinical decisions must be made with your licensed healthcare provider.

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