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Sexual & Reproductive Health

Clomiphene Citrate

Also known as Clomid · Serophene · clomifene

Clinically studiedOralFDA-approved for female ovulation induction; use in men for hypogonadism is off-label

Clomiphene citrate is a selective estrogen receptor modulator (SERM) that contains both the enclomiphene and zuclomiphene isomers. By antagonizing estrogen receptors at the pituitary it increases LH and FSH, raising the body's own testosterone production. It is FDA-approved for ovulation induction in women and is used off-label in men for hypogonadism, often when preserving fertility is a goal.

Studied / used for

  • Studied for ovulation induction in women
  • Studied off-label for male hypogonadism
  • Studied for raising testosterone while maintaining fertility

Commonly reported side effects

  • Mood changes
  • Breast tenderness
  • Visual disturbances (less common)
  • Hot flashes
  • Rise in estradiol
Clinically studied. Supported by human clinical trials. This reflects the strength of the research base, not effectiveness or a recommendation.

Not medical advice.

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