Hormones & TRT/HRT Adjuncts

DHEA

Also known as dehydroepiandrosterone · prasterone · Intrarosa

Emerging researchOralVaginal (prasterone)Sold as a dietary supplement in the US (not regulated by the FDA as a drug in that form); one prescription form (prasterone/Intrarosa) is FDA-approved; banned in sport (WADA)

DHEA (dehydroepiandrosterone) is an endogenous steroid hormone produced by the adrenal glands, not a peptide. It serves as a precursor that the body can convert into androgens and estrogens. It is widely sold as a dietary supplement; the prescription form prasterone is FDA-approved for one specific vaginal indication. Evidence for many of its popular uses is limited.

Studied / used for

Studied as a hormone precursor in the context of low DHEA states and aging
FDA-approved (as prasterone) for moderate-to-severe dyspareunia due to vulvovaginal atrophy
Studied with mixed or limited evidence for mood, bone, and sexual function

Commonly reported side effects

Acne
Oily skin
Increased facial or body hair
Hair changes
Mood changes
Potential effects on hormone-sensitive tissues

Emerging research. Active research; human evidence still developing. This reflects the strength of the research base, not effectiveness or a recommendation.

Not medical advice.

This is an educational reference. Peptalk does not recommend, prescribe, endorse, or rate any compound, and provides no dosing information. Do not start, stop, or change any peptide, hormone, supplement, or therapy based on this page. All clinical decisions must be made with your licensed healthcare provider.

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