Hormones & TRT/HRT Adjuncts

Enclomiphene Citrate

Also known as enclomifene · Androxal · trans-clomiphene

Clinically studiedOralNot FDA-approved (development as a standalone product was discontinued after a Complete Response Letter in 2015); available in the US only via compounding pharmacies by prescription; prescription drug, not a dietary supplement; banned in sport (WADA)

Enclomiphene is the trans-isomer of clomiphene and is a selective estrogen receptor modulator (SERM), not a peptide. By blocking estrogen feedback at the hypothalamus and pituitary, it increases secretion of LH and FSH, which in turn stimulates the testes to produce more testosterone. Because it raises the body's own testosterone, it has been studied as a fertility-preserving alternative to direct testosterone replacement in men with secondary hypogonadism.

Studied / used for

Studied for raising endogenous testosterone in men with secondary (hypogonadotropic) hypogonadism
Studied as a fertility-preserving approach compared with testosterone replacement
Used in protocols intended to maintain sperm production

Commonly reported side effects

Headache
Nausea
Diarrhea
Hot flashes
Dizziness
Joint pain (arthralgia)
Rarely, blood clots or cardiac events in predisposed individuals

Clinically studied. Supported by human clinical trials. This reflects the strength of the research base, not effectiveness or a recommendation.

Not medical advice.

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