Sexual & Reproductive Health

Enclomiphene Citrate

Also known as Enclomiphene · Androxal · trans-clomiphene

Emerging researchOralNot FDA-approved (branded Androxal received an FDA Complete Response Letter in 2015 and was never approved); available through compounding pharmacies

Enclomiphene is the trans-isomer of clomiphene and a selective estrogen receptor modulator (SERM). By blocking estrogen receptors at the pituitary, it increases LH and FSH output, which raises the body's own testosterone production while tending to preserve sperm production. It has been studied as a fertility-preserving alternative to testosterone replacement in men with secondary hypogonadism.

Studied / used for

Studied for secondary (hypogonadotropic) hypogonadism in men
Studied for raising endogenous testosterone while maintaining spermatogenesis
Studied as a fertility-sparing alternative to TRT

Commonly reported side effects

Headache
Gastrointestinal upset
Transient rise in estradiol
Generally fewer estrogenic effects than clomiphene

Emerging research. Active research; human evidence still developing. This reflects the strength of the research base, not effectiveness or a recommendation.

Not medical advice.

This is an educational reference. Peptalk does not recommend, prescribe, endorse, or rate any compound, and provides no dosing information. Do not start, stop, or change any peptide, hormone, supplement, or therapy based on this page. All clinical decisions must be made with your licensed healthcare provider.

← Back to all compounds