Longevity & Mitochondrial

Epitalon (Epithalon)

Also known as Epitalon · Epithalon · Epithalone · Ala-Glu-Asp-Gly · AEDG peptide

AnecdotalSubcutaneousIntramuscularNot FDA-approved; sold as a research chemical, not legally marketed for human consumption. The FDA has flagged it among compounded peptides over immunogenicity and safety concerns

Epitalon is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) developed in Russia as an analog of epithalamin, a pineal gland extract. It is studied for its reported ability to influence telomerase activity, melatonin production, and circadian rhythm. Most of the research consists of Russian-language studies from a single research group spanning several decades, with essentially no independent Western clinical replication, so its anti-aging claims remain unproven in humans.

Studied / used for

Studied for telomerase activity in cell cultures
Researched in the context of circadian rhythm and melatonin regulation
Studied in the context of geroprotective and neuroendocrine effects
Researched for immune and pineal function

Commonly reported side effects

Injection site redness or irritation
Mild headache or dizziness
Transient fatigue or lethargy
Occasional sleep changes
Potential immunogenicity (a concern flagged by the FDA)

Anecdotal. Limited formal evidence; reports are largely anecdotal. This reflects the strength of the research base, not effectiveness or a recommendation.

Not medical advice.

This is an educational reference. Peptalk does not recommend, prescribe, endorse, or rate any compound, and provides no dosing information. Do not start, stop, or change any peptide, hormone, supplement, or therapy based on this page. All clinical decisions must be made with your licensed healthcare provider.

← Back to all compounds