Tissue Repair & Recovery

GHK-Cu

Also known as Copper tripeptide-1 · Copper peptide · Glycyl-L-histidyl-L-lysine copper complex · GHK copper

Emerging researchTopicalSubcutaneous injection (research/compounded)Not FDA-approved as a drug. Sold as a topical cosmetic ingredient. Injectable/compounded use is not FDA-approved and has been flagged by the FDA over safety concerns; injectable GHK-Cu was among peptides removed from the FDA interim 503A Category 2 bulks list in April 2026, pending further regulatory review.

GHK-Cu is a naturally occurring tripeptide (glycyl-histidyl-lysine) bound to copper, the levels of which decline with age. Research describes it influencing collagen and elastin synthesis, supporting new blood-vessel formation in wounds, and modulating protease enzymes involved in tissue remodeling. It is most characterized for topical skin and hair applications, where it appears in many cosmetic serums and creams; injectable use is far less studied.

Studied / used for

Studied topically for skin renewal and collagen/elastin support
Studied for wound healing and tissue remodeling
Investigated for hair follicle stimulation
Studied for antioxidant and anti-inflammatory effects in skin

Commonly reported side effects

Skin irritation or redness reported with topical use
Anecdotal reports of skin laxity or puffiness with heavy use (possible metalloproteinase overstimulation)
Injectable forms: limited human data; FDA has noted immunogenicity/aggregation concerns

Emerging research. Active research; human evidence still developing. This reflects the strength of the research base, not effectiveness or a recommendation.

Not medical advice.

This is an educational reference. Peptalk does not recommend, prescribe, endorse, or rate any compound, and provides no dosing information. Do not start, stop, or change any peptide, hormone, supplement, or therapy based on this page. All clinical decisions must be made with your licensed healthcare provider.

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