Longevity & Mitochondrial

Glutathione

Also known as Glutathione · GSH · Reduced glutathione · L-glutathione

Emerging researchOralIntravenousIntramuscularNebulizedLegal as an oral dietary supplement; injectable/IV glutathione is an unapproved drug, and the FDA has issued safety warnings about its use in compounded sterile injectables

Glutathione is an antioxidant tripeptide made in the body from three amino acids that helps neutralize free radicals, supports detoxification, and maintains cellular redox balance. It is used orally as a supplement and offered by some clinics as an intravenous or injectable preparation, including for skin-lightening. Evidence for systemic and cosmetic benefits is mixed, and dermatology and pharmacology reviews caution against injectable use for skin lightening given limited evidence and safety concerns.

Studied / used for

Studied for oxidative stress and antioxidant capacity
Researched for detoxification and liver support
Studied for skin-lightening (with safety concerns noted)
Researched in the context of insulin resistance and fatty liver

Commonly reported side effects

Nausea
Injection site discomfort
Reported liver dysfunction in some skin-lightening studies
Rare anaphylaxis
Caution noted in research with asthma, kidney disease, or sulfur sensitivity

Emerging research. Active research; human evidence still developing. This reflects the strength of the research base, not effectiveness or a recommendation.

Not medical advice.

This is an educational reference. Peptalk does not recommend, prescribe, endorse, or rate any compound, and provides no dosing information. Do not start, stop, or change any peptide, hormone, supplement, or therapy based on this page. All clinical decisions must be made with your licensed healthcare provider.

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