Sexual & Reproductive Health

Gonadorelin

Also known as GnRH · LHRH · Factrel · Lutrepulse

Clinically studiedSubcutaneous injectionIntravenousPulsatile pump infusionBranded products (Factrel for diagnostic use, Lutrepulse for ovulation induction) were previously FDA-approved but have been discontinued; no FDA-approved gonadorelin product is currently marketed in the US, and it is now generally available via compounding

Gonadorelin is a synthetic form of gonadotropin-releasing hormone (GnRH) that acts on the pituitary to stimulate LH and FSH release. Its effect depends heavily on how it is delivered: pulsatile exposure tends to stimulate the axis, whereas continuous high-level exposure can desensitize the pituitary and suppress gonadotropins. It has been studied in contexts intended to support the reproductive axis, including alongside testosterone therapy.

Studied / used for

Studied for diagnostic testing of pituitary function
Studied for inducing ovulation in hypothalamic amenorrhea
Studied for maintaining testicular function during TRT

Commonly reported side effects

Headache
Flushing
Nausea
Injection-site reactions
With sustained exposure, hypogonadal symptoms such as hot flashes, reduced libido and fatigue

Clinically studied. Supported by human clinical trials. This reflects the strength of the research base, not effectiveness or a recommendation.

Not medical advice.

This is an educational reference. Peptalk does not recommend, prescribe, endorse, or rate any compound, and provides no dosing information. Do not start, stop, or change any peptide, hormone, supplement, or therapy based on this page. All clinical decisions must be made with your licensed healthcare provider.

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