Longevity & Mitochondrial

Humanin

Also known as Humanin · HN · HNG (analog)

PreliminarySubcutaneousNot FDA-approved; sold as a research compound, not legally marketed for human consumption

Humanin is a mitochondrial-derived peptide encoded within the mitochondrial genome that functions as a cellular survival signal, studied for its role in protecting cells from oxidative stress, inflammation, and apoptosis. It was first identified for protecting neurons against amyloid-beta toxicity. Plasma humanin levels decline with age and correlate with longevity in animal models, and overexpression has been reported to extend lifespan in C. elegans. The evidence is largely preclinical, drawn from cell and animal studies, with little human clinical data.

Studied / used for

Studied for neuroprotection in cell models
Researched in the context of mitochondrial integrity and cellular survival
Studied for metabolic healthspan in animal models
Researched in the context of IGF-1 signaling and inflammation

Commonly reported side effects

Injection site reactions
Limited human safety data available
Side effect profile not well characterized in humans

Preliminary. Mostly early or animal studies. This reflects the strength of the research base, not effectiveness or a recommendation.

Not medical advice.

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