Sexual & Reproductive Health

Melanotan II

Also known as MT-II · MT2 · Melanotan 2

AnecdotalSubcutaneous injectionIntranasalNot approved for human use in the US, UK, EU, Canada or Australia; on the FDA bulk-compounding Category 2 list (cannot be compounded); reclassified to a prohibited substance (Schedule 9) in Australia in 2026

Melanotan II is a synthetic analog of alpha-melanocyte-stimulating hormone that activates multiple melanocortin receptors, including MC1R (driving melanin production and skin tanning) and MC4R/MC3R (associated with appetite and sexual arousal effects). It is the broader, less receptor-selective predecessor from which the more selective PT-141 was developed. It is not approved for human use.

Studied / used for

Associated in research with skin pigmentation and UV-independent tanning
Associated in research with sexual arousal and erectile effects
Associated in research with appetite effects

Commonly reported side effects

Nausea
Flushing
Spontaneous erections
Darkening of moles, freckles and new nevi
Fatigue and yawning
Blood pressure changes

Anecdotal. Limited formal evidence; reports are largely anecdotal. This reflects the strength of the research base, not effectiveness or a recommendation.

Not medical advice.

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