Metabolic & Weight Management

MOTS-c

Also known as Mitochondrial ORF of the twelve S rRNA type-c · mitochondrial-derived peptide

PreliminarySubcutaneous injectionNot FDA-approved for any indication; research compound. Not an approved drug; sometimes obtained via compounding pharmacies or research-chemical suppliers.

MOTS-c is a short peptide encoded within the mitochondrial 12S rRNA gene. In preclinical models it activates AMPK signaling and influences glucose, fatty-acid, and mitochondrial metabolism, and it has been described as an exercise-responsive regulator of metabolic homeostasis. Most evidence is from cell and animal studies; human work is early and largely observational.

Studied / used for

researched for metabolic homeostasis and insulin sensitivity
researched for exercise physiology and mitochondrial function
researched for diet-induced weight gain in animal models

Commonly reported side effects

injection-site reactions
limited human safety data reported

Preliminary. Mostly early or animal studies. This reflects the strength of the research base, not effectiveness or a recommendation.

Not medical advice.

This is an educational reference. Peptalk does not recommend, prescribe, endorse, or rate any compound, and provides no dosing information. Do not start, stop, or change any peptide, hormone, supplement, or therapy based on this page. All clinical decisions must be made with your licensed healthcare provider.

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