Longevity & Mitochondrial

NAD+ (Nicotinamide Adenine Dinucleotide)

Also known as NAD · NAD+ · Nicotinamide adenine dinucleotide

Emerging researchIntravenousSubcutaneousIntramuscularNot FDA-approved as a drug; injectable/IV NAD+ is an unapproved drug typically prepared by compounding pharmacies for clinic use

NAD+ is an essential coenzyme found in every cell that is required for mitochondrial ATP production and serves as a cofactor for enzymes involved in DNA repair, gene regulation, and cellular metabolism. Tissue NAD+ levels decline with age, which is the basis for interest in restoring it. Some clinics offer it as an intravenous or injectable preparation. Raising NAD+ levels has been demonstrated in research, but whether this translates to improved human healthspan or longevity remains unproven.

Studied / used for

Studied in the context of age-related decline in cellular NAD+ levels
Studied for mitochondrial energy metabolism
Used in some wellness settings for fatigue and recovery
Researched in the context of metabolic and neurological function

Commonly reported side effects

Flushing
Chest tightness during infusion
Shortness of breath during infusion
Palpitations
Nausea
Abdominal cramping
Headache

Emerging research. Active research; human evidence still developing. This reflects the strength of the research base, not effectiveness or a recommendation.

Not medical advice.

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