Cognitive & Neuro

P21 (P021)

Also known as P021 · P-21 · Ac-DGGLAG-NH2 · CNTF peptide mimetic

PreliminaryOralSubcutaneous injectionNot FDA-approved; no published human safety or efficacy data; remains a preclinical research compound sold as a research chemical

P21 (P021) is a synthetic adamantane-modified tetrapeptide derived from the active region of human ciliary neurotrophic factor (CNTF). In preclinical work it is described as a neurogenic and neurotrophic compound that enhances dentate gyrus neurogenesis by inhibiting LIF signaling and increasing BDNF expression, and that reduces abnormal tau hyperphosphorylation via BDNF-mediated decreases in GSK-3 beta activity. It is reported to be blood-brain-barrier permeable and orally available in animal models. It remains an investigational compound without human safety or efficacy data.

Studied / used for

studied in rodent models for neurogenesis and synaptic plasticity
studied for tau pathology and Alzheimer's-type changes
explored for cognitive deficits in transgenic models

Commonly reported side effects

no human safety data; the side-effect profile in humans is uncharacterized

Preliminary. Mostly early or animal studies. This reflects the strength of the research base, not effectiveness or a recommendation.

Not medical advice.

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