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Cognitive & Neuro

Pinealon

Also known as Pineal bioregulator · EDR peptide · Glu-Asp-Arg

PreliminarySubcutaneous injectionIntranasalOralNot FDA-approved for any human therapeutic use; in the U.S. it is sold only as a research chemical labeled "not for human consumption." It is not listed as a compounding-eligible bulk substance on the FDA 503A or 503B lists (and was not added in the April 2026 bulks-list updates). It is not a controlled substance under the U.S. Controlled Substances Act. In Russia, peptide bioregulators of this type have been marketed for years under a different regulatory framework. Pinealon is not listed by name on the WADA Prohibited List, though peptide hormones, growth factors, and related/mimetic substances are addressed as a category, so status should be verified against the current WADA list.

Pinealon is a short synthetic tripeptide (glutamic acid-aspartic acid-arginine, also called the EDR peptide) developed by Vladimir Khavinson's group at the St. Petersburg Institute of Bioregulation and Gerontology, where it is grouped with the "peptide bioregulators." In cell-culture and rodent studies it has been reported to reduce reactive oxygen species, limit neuronal apoptosis, and influence the expression of genes tied to antioxidant defense and anti-apoptotic signaling, with proposed activity via DNA-binding and MAPK/ERK pathways. Human data are very limited, largely come from a single research network, and have not been confirmed by independent controlled trials. Pinealon is not approved by the FDA for any medical use and is sold in the United States only as a research chemical labeled "not for human consumption." This entry is educational and is not a recommendation or endorsement of use.

Studied / used for

  • Investigated for neuroprotection against oxidative stress, hypoxia, and ischemia in laboratory models
  • Studied for effects on memory, attention, and cognitive function in aging-related research
  • Investigated for regulation of gene expression and antioxidant/anti-apoptotic signaling in neuronal cells
  • Studied in research contexts related to traumatic brain injury and cerebrasthenia

Commonly reported side effects

  • No controlled human safety data; the side-effect profile in humans is poorly characterized
  • Injection-site reactions such as mild redness, discomfort, or swelling reported anecdotally with injectable use
  • Headache reported anecdotally
  • Mild, short-lived fatigue reported anecdotally
Preliminary. Mostly early or animal studies. This reflects the strength of the research base, not effectiveness or a recommendation.

Not medical advice.

This is an educational reference. Peptalk does not recommend, prescribe, endorse, or rate any compound, and provides no dosing information. Do not start, stop, or change any peptide, hormone, supplement, or therapy based on this page. All clinical decisions must be made with your licensed healthcare provider.

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