Hormones & TRT/HRT Adjuncts

Pregnenolone

Also known as P5 · 3 beta-hydroxy-5-pregnen-20-one

PreliminaryOralMarketed as a dietary supplement in the US though it functions hormonally; not FDA-approved as a drug; not currently on the WADA prohibited list (status can change with annual updates)

Pregnenolone is an endogenous steroid hormone synthesized from cholesterol, not a peptide. It sits at the top of the steroidogenesis pathway and is a precursor to other steroid hormones including progesterone, DHEA, and downstream sex steroids and corticosteroids. It is marketed as a dietary supplement; rigorous clinical evidence for its common purported benefits is limited.

Studied / used for

Studied as an upstream steroid precursor in hormonal-support contexts
Studied with preliminary or limited evidence for memory, mood, and cognition
Used anecdotally in wellness protocols as a hormone precursor

Commonly reported side effects

Gastrointestinal upset
Headache
Mood changes (excitement or agitation)
Acne or skin changes
Drowsiness
Potential effects on hormone-sensitive tissues

Preliminary. Mostly early or animal studies. This reflects the strength of the research base, not effectiveness or a recommendation.

Not medical advice.

This is an educational reference. Peptalk does not recommend, prescribe, endorse, or rate any compound, and provides no dosing information. Do not start, stop, or change any peptide, hormone, supplement, or therapy based on this page. All clinical decisions must be made with your licensed healthcare provider.

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