Hormones & TRT/HRT Adjuncts
Progesterone (Micronized)
Also known as micronized progesterone · Prometrium · P4
Clinically studiedOralVaginalIntramuscular injectionFDA-approved (e.g., for endometrial protection and secondary amenorrhea); prescription only
Progesterone is a naturally occurring steroid hormone, not a peptide. Micronized (bioidentical) progesterone is a form commonly used in hormone therapy. In menopausal hormone therapy it is combined with estrogen in women who have a uterus to oppose estrogen's effect on the endometrium and reduce the risk of endometrial overgrowth.
Studied / used for
- Used in menopausal hormone therapy to protect the endometrium when estrogen is given to women with a uterus
- Studied and used to support the uterine lining in assisted reproduction
- Used in protocols addressing sleep and certain menopausal symptoms
Commonly reported side effects
- Drowsiness or sedation
- Dizziness
- Breast tenderness
- Bloating
- Fatigue
- Headache
- Mood changes
- Vaginal discharge (with vaginal use)
Clinically studied. Supported by human clinical trials. This reflects the strength of the research base, not effectiveness or a recommendation.
Not medical advice.
This is an educational reference. Peptalk does not recommend, prescribe, endorse, or rate any compound, and provides no dosing information. Do not start, stop, or change any peptide, hormone, supplement, or therapy based on this page. All clinical decisions must be made with your licensed healthcare provider.