Sexual & Reproductive Health

PT-141 (Bremelanotide)

Also known as Bremelanotide · Vyleesi · PT141

Clinically studiedSubcutaneous injectionIntranasalFDA-approved as Vyleesi for HSDD in premenopausal women; other uses are off-label or via compounding

PT-141 (bremelanotide) is a synthetic melanocortin peptide that acts centrally, primarily as an agonist at the MC4 receptor in the hypothalamus, rather than on the vascular pathways targeted by PDE5 inhibitors. It is thought to influence neural circuits associated with sexual desire and arousal. It was derived from the broader melanocortin agonist Melanotan II after researchers observed arousal-related effects during pigmentation studies.

Studied / used for

Studied for hypoactive sexual desire disorder (HSDD) in premenopausal women
Studied for low sexual desire and arousal
Studied for erectile response in men

Commonly reported side effects

Nausea
Flushing
Headache
Injection-site reactions
Transient increases in blood pressure
Darkening of skin or moles

Clinically studied. Supported by human clinical trials. This reflects the strength of the research base, not effectiveness or a recommendation.

Not medical advice.

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