Cognitive & Neuro

Selank

Also known as Thr-Lys-Pro-Arg-Pro-Gly-Pro · Tuftsin analog · TP-7

Emerging researchIntranasalSubcutaneous injectionRegistered in Russia for generalized anxiety disorder and as a nootropic; not FDA-approved in the United States; not a US controlled substance; placed by FDA on the §503A Category 2 bulk drug substances list, so it is not covered by enforcement discretion for pharmacy compounding

Selank is a synthetic heptapeptide analog of the immunomodulatory tetrapeptide tuftsin, stabilized by added proline residues. Its most studied proposed mechanisms include modulation of the GABAergic system, inhibition of enkephalin-degrading enzymes, BDNF upregulation, and effects on serotonin and dopamine turnover. Research describes anxiolytic activity reported without the sedation, cognitive impairment, or dependence associated with benzodiazepines.

Studied / used for

studied for generalized anxiety disorder and neurasthenia in Russian trials
used in protocols for anxiety and stress without sedation
studied for mood and cognitive support

Commonly reported side effects

mild taste or odor irritation with intranasal use
occasional headache
transient fatigue or drowsiness
dizziness

Emerging research. Active research; human evidence still developing. This reflects the strength of the research base, not effectiveness or a recommendation.

Not medical advice.

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