Cognitive & Neuro

Semax

Also known as ACTH(4-10) analog · Met-Glu-His-Phe-Pro-Gly-Pro · Heptapeptide Semax

Emerging researchIntranasalSubcutaneous injectionRegistered in Russia and some CIS countries as a nootropic/neuroprotective drug; not FDA-approved in the United States; not a US controlled substance; placed by FDA on the §503A Category 2 bulk drug substances list, so it is not covered by enforcement discretion for pharmacy compounding

Semax is a synthetic heptapeptide analog of the ACTH(4-10) fragment, developed at the Institute of Molecular Genetics of the Russian Academy of Sciences. It is proposed to act by upregulating BDNF and NGF and modulating dopaminergic, serotonergic, and cholinergic systems, with downstream neurotrophic effects that are described as outlasting its very short plasma half-life. Mechanistic work in animal models also points to reduced excitotoxicity and oxidative stress in ischemia.

Studied / used for

used in Russian clinical protocols for cognitive impairment and concentration
studied for ischemic stroke recovery
studied for neuroprotection and BDNF/NGF upregulation

Commonly reported side effects

nasal mucosa irritation or dryness with intranasal use
headache
transient changes in alertness or mild anxiety
occasional dizziness

Emerging research. Active research; human evidence still developing. This reflects the strength of the research base, not effectiveness or a recommendation.

Not medical advice.

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