Tissue Repair & Recovery

TB-500

Also known as Thymosin Beta-4 fragment · TB4 synthetic analog · Tβ4 acetate (research form)

PreliminarySubcutaneous injectionIntramuscular injectionNot FDA-approved; treated as an unapproved drug / research chemical not permitted for human consumption. Was among peptides removed from the FDA interim 503A Category 2 bulks list in April 2026 and is scheduled for Pharmacy Compounding Advisory Committee (PCAC) review beginning July 2026. Prohibited in sport by WADA.

TB-500 is a synthetic peptide related to the actin-binding region of thymosin beta-4 and is commonly encountered in the research-and-recovery space. In animal and early studies it has been reported to influence cell migration, angiogenesis, and inflammation, which has been associated with soft-tissue and wound recovery. Large-scale controlled human trials for musculoskeletal use are lacking, so much of the supporting evidence is preclinical or anecdotal.

Studied / used for

Studied in animal models for soft-tissue and wound healing
Investigated for promoting cell migration and angiogenesis
Studied in injury-recovery research for muscle and tendon tissue
Studied for inflammation-related signaling in animal models

Commonly reported side effects

Fatigue reported anecdotally
Headache reported anecdotally
Injection-site redness or swelling
Temporary mood changes reported anecdotally; human safety data limited

Preliminary. Mostly early or animal studies. This reflects the strength of the research base, not effectiveness or a recommendation.

Not medical advice.

This is an educational reference. Peptalk does not recommend, prescribe, endorse, or rate any compound, and provides no dosing information. Do not start, stop, or change any peptide, hormone, supplement, or therapy based on this page. All clinical decisions must be made with your licensed healthcare provider.

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