Tissue Repair & Recovery
Thymosin Beta-4 (Tβ4)
Also known as TB4 · Thymosin β4 · RGN-259 (ophthalmic formulation) · TB-500 (often conflated)
Thymosin beta-4 is a naturally occurring 43-amino-acid peptide found in many tissues and cell types that plays a role in actin regulation, cell migration, and tissue repair. As the investigational ophthalmic solution RGN-259, the full-length molecule has a formal pharmaceutical development track and has been evaluated in controlled human trials, including Phase 3 studies, for corneal conditions such as neurotrophic keratopathy and dry eye, with mixed results across trials. It has also been studied in animal models for skin, heart, and nervous-system repair. Injectable forms used outside the ophthalmic program have not been established in controlled human trials.
Studied / used for
- Studied in controlled human trials (as the investigational ophthalmic drug RGN-259), including Phase 3, for neurotrophic keratopathy and dry eye
- Investigated in animal models for skin and corneal wound healing
- Studied in animal models for cardiac and nervous-system tissue repair
- Studied for inflammation-related signaling and cell migration in preclinical models
Commonly reported side effects
- Generally reported as well tolerated in ophthalmic trials
- Eye irritation or discomfort reported with ophthalmic use
- Injection-site reactions reported with injectable research forms; human safety data for injectable use are limited
Not medical advice.
This is an educational reference. Peptalk does not recommend, prescribe, endorse, or rate any compound, and provides no dosing information. Do not start, stop, or change any peptide, hormone, supplement, or therapy based on this page. All clinical decisions must be made with your licensed healthcare provider.