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Tissue Repair & Recovery

VIP (Vasoactive Intestinal Peptide)

Also known as Vasoactive Intestinal Polypeptide · Aviptadil (synthetic form) · VIP nasal spray

Emerging researchIntranasalSubcutaneous injectionIntravenous infusion (aviptadil, trial settings)Not FDA-approved for wellness/CIRS use; the synthetic form aviptadil has been studied in clinical trials. Available as a compounded nasal spray by prescription; under FDA review as a bulk compounding substance.

Vasoactive intestinal peptide is a naturally occurring 28-amino-acid signaling peptide with roles in vasodilation and immune modulation, including downregulation of pro-inflammatory cytokines from immune cells. Its synthetic form (aviptadil) has been studied intravenously and by inhalation in lung conditions such as ARDS. In wellness settings it is used as a compounded nasal spray, often in the context of chronic inflammatory response syndrome (CIRS), a diagnosis that is not broadly accepted; the FDA has noted insufficient data on its safety for chronic use.

Studied / used for

  • Studied for anti-inflammatory and immune-modulating effects
  • Investigated (as aviptadil) for acute respiratory distress syndrome
  • Used in some compounded protocols in the context of chronic inflammatory response syndrome (CIRS, a diagnosis that is not broadly accepted)
  • Studied for vasodilation and pulmonary conditions

Commonly reported side effects

  • Flushing and lowered blood pressure (vasodilation)
  • Diarrhea
  • Nasal irritation with nasal-spray use
  • FDA has flagged insufficient safety data for chronic use
Emerging research. Active research; human evidence still developing. This reflects the strength of the research base, not effectiveness or a recommendation.

Not medical advice.

This is an educational reference. Peptalk does not recommend, prescribe, endorse, or rate any compound, and provides no dosing information. Do not start, stop, or change any peptide, hormone, supplement, or therapy based on this page. All clinical decisions must be made with your licensed healthcare provider.

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